Survival Effect of pCR Elusive in Breast Cancer 80% lower risk of recurrence with surrogate endpoint, but link to survival unproven Jul 23, 2020
Spravato Debate Still Rages Journal airs questions about efficacy data, potential for harm Feb 20, 2020
Meet the 'Lien Doctors'; Hidden Clinical Trial Data; Google Nabs More Medical Records This past week in healthcare investigations Jan 15, 2020
Entresto Holds Up in the Real World ... But Not for Everyone Drug not better than ACE inhibitor, ARB for black patients? Dec 12, 2019
FDA Warns Liveyon Over Cord Blood Stem Cell Products Company slapped for distributing unapproved products, deviating from quality manufacturing practices Dec 09, 2019
Depth of Tumor Response a Better Survival Predictor Could improve on RECIST as outcome measure in oncology Jun 05, 2019
Want to Know If Someone Is Manipulating Data? Milton Packer describes how to distinguish science from magic Feb 27, 2019
Inhaled Hypertonic Saline Safe, Effective in Infants With CF Study shows that randomized trials are feasible among those under 4 months Nov 09, 2018
I'm Drowning A researcher-patient's plea for broader inclusion in cystic fibrosis trials Oct 11, 2018
State Boards Turn Blind Eye to FDA-Sanctioned Docs Dozens got warning letters for serious ethical lapses, but nearly all faced no state discipline Aug 16, 2018
First Clinical Trial in Medicine Changed World History Milton Packer revisits a 1747 medical landmark and its tortuous aftermath Aug 15, 2018
TB Vaccine for T1D Study Stirs Controversy Long-term data suggest BCG vaccine may alter immune attack Jun 25, 2018
Key Mediterranean Diet Trial Retracted But republished results show same advantage after excluding protocol violations Jun 13, 2018
Clinical Trials Need to be More Inclusive, Experts Say Children, seniors, and chronic disease patients need more options Apr 17, 2018
'Unsolved Mysteries' on Display at AACR Large, diverse program reflects rapid pace of advancement Apr 13, 2018
Gyn Cancer Research Gets Short Shrift in Funding Mortality-adjusted analysis shows huge disparity versus other cancers Mar 25, 2018
AHA: Everybody Now Is a Clinical Investigator, Says Califf Time to revolutionize clinical data gathering, ex-FDA Commissioner urges Nov 15, 2017
Device May Ease Fistula Creation Catheter-based, ultrasound-guided device had good long-term patency Nov 08, 2017
Rituxan Has Promise in Idiopathic Nephropathy B-cell targeting with rituximab seems as effective as with cyclosporine Nov 06, 2017
We Have Ruined Late-Breaking Clinical Trials in Cardiology In this Revolution and Revelation, Milton Packer explains why a cornerstone of annual meetings has gone from sizzler to snoozer Aug 23, 2017
Vinay Prasad, MD, on 'Medical Reversal' 'Not every reversal puts money in doctors' pockets' Aug 17, 2017 video
Morning Break: Tainted Trials; $40K/Yr Concierge Practice; Reality TV: Diabetes Health news and commentary from around the Web gathered by the 51˶ staff Jun 05, 2017
Are Propensity Scores As Good As Randomized Trials? They may not offer much more than multivariable adjustment May 22, 2017 video
CardioBrief: Serious Questions Raised About Validity Of International Trials TOPCAT analysis is the 'smoking gun' for trouble from 'offshoring' trials Apr 26, 2017
Scott Gottlieb's Sham Ideology Rejects Clinical Trials The next FDA commissioner doesn't believe in trials with sham controls Mar 14, 2017
MSK Cancer Alliance: Mainly About Medicine Bi-directional relationship strengthens regional cancer care Mar 11, 2017
'Jurassic' Clinical Trial Yields Prostate Cancer Guidance Negative trial informs new studies of adjuvant therapy Feb 17, 2017
Lies, Damned Lies, and P Values F. Perry Wilson, MD, delves into the oft-misunderstood statistic Dec 29, 2016 video
TCT: For Heart Devices, Will Lag Moving from Europe to U.S. Wane? FDA Commissioner and E.U. representative talk change Nov 02, 2016
Why a Missed Primary Endpoint Isn't the End of the Road Many 'negative' studies would be better described as uninformative Sep 01, 2016 video
Afib: Poor Short-Term Outcomes More Common After Stenting But where is that expected link between Afib and stroke? Aug 22, 2016
CardioBrief: Diet Drug Loses Another Cardiovascular Outcomes Trial More chaos over the weight loss drug Contrave Apr 13, 2016
CardioBrief: Top HF Expert Decries 'Unbelievable Folly' of Clinical Trials and Guidelines Milton Packer, MD, calls the system to test and evaluate heart failure drugs dysfunctional Mar 23, 2016
SEER Data Errors: NCI Looks To Avoid Repeats Results reassuring as SEER audit nears completion Dec 23, 2015
FDA Presses Pause on Novel Testosterone Product Gives FDA chance to "back away from the circus," says sponsor's CEO Nov 02, 2015
Hybrid Academic-Community Cancer Centers Take Shape Emerging model takes cutting-edge oncology into the community Aug 31, 2015
HypeWatch: Cannabis Bone-Healing Study Oversold Forget the headlines you read. Here's what you should know. Jul 23, 2015
How ASCO'S First Clinical Trial -- TAPUR -- Came To Be ASCO's entry will evaluate off-label use of targeted agents Jun 02, 2015
Neurologists Back FDA on Call for ALS Drug Data Experts want Genervon to release all of its trial results for an investigational ALS drug that's already gained patient support. Apr 21, 2015
