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Clinical Trials

A photo of a Hispanic woman laying in a hospital bed during a chemotherapy session.

Rates of Consent Withdrawal in Cancer Trials Low but Not 'Trivial'

Factors associated with greater likelihood of withdrawal included Hispanic ethnicity, older age

A photo of a pipette hovering over a petri dish laying on genetic testing results.

How to Overcome the Catch-22 in Precision Medicine Research

Improving the patient experience will go a long way

Forging the Path to a West Nile Vaccine

Alternative approaches to licensure are key, says CDC's Carolyn Gould

A photo of the signage outside of the FDA headquarters in Washington, D.C.

FDA Has Neglected Clinical Trial Transparency 鈥� Plus $45 Billion in Fines

It's time for more aggressive enforcement of the law

A photo of a man holding out a check.

It's Time to Pay Clinical Trial Participants More

Accelerating trial enrollment can catalyze access to much-needed medications

A photo of Frank Pallone during a hearing.

FDA, NIH Must Penalize Researchers Who Don't Report Trial Results, House Member Says

Many with NIH grants don't follow reporting rules, get funded again anyway, says Rep. Pallone

Makena Is Just the Latest in Accelerated Approval Mayhem

Congress must take action to reform the process

A photo of Howard Bauchner, MD

Ex-JAMA Chief: Cut the Hype, Spin in Published Studies

Howard Bauchner, MD, says researchers want to report accurately, but "they too have their biases"

A photo of a box of Relyvrio.

Why I Voted 'No' on the New ALS Drug

Here are the shortcomings I saw in the phase II Relyvrio study

A photo of a female physician discussing a body mass index chart with an overweight teen boy.

Our Hands Are Tied: Treating Prediabetes in Kids

We urgently need more research on pharmacological interventions for this growing epidemic

A photo of the packaging and blisterpack of Paxlovid.

What's Really Driving COVID 'Rebound' After Paxlovid?

There's only one way to find out

Making Observational Studies More Reliable

Harlan Krumholz, MD, discusses a new path to less bias, more transparency

A computer rendering of a syringe pointing at the bones of the knee

Lubricant Shots for Knee OA: No, They Really Don't Help

Meta-analysis of hyaluronic acid trials throws serious shade on common practice

ASCO over a photo of McCormick Place in Chicago, IL.

Black Patients Often Never Given a Chance to Join Breast Cancer Trials

But survey finds several actionable findings that could boost enrollment

ATS over a photo of the San Francisco Marriott in San Francisco, CA

Six COVID Treatments Entered Rapid Testing, All Failed

I-SPY results seen as testament to new adaptive trials

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Inside Hospital Hacker Mob; Clinical Trial Surprise Bill; Silenced Nurses

This past week in healthcare investigations

A bottle of Fluvoxamine Maleate tablets over a computer rendering of COVID viruses

Doctor Submits Fluvoxamine EUA Application to FDA

Group of physician-scientists believes data support authorization for treating COVID-19

A photo of a box and blister pack of Ivermectin tablets.

Ivermectin Arm of PRINCIPLE Trial Put on Hold

Trial website cites supply issues

A colorful collage of the cosmos with a large eye in the center.

Academic Centers Start to Take Psychedelics Seriously

"You're not sticking your neck out as much as you would 10 years ago," one director says

A colorful abstract illustration of a human brain and head silhouette and the cosmos.

Is Psychedelic Research Funding Starting to Shift?

Once the province of philanthropy, industry and government sources show interest

A computer rendering of arrows colliding with a brick wall, one reverses, one is stopped, one breaks through.

Reversal, Replacement, and Reassessment in Medicine

Three ways medical science progresses and what this has to do with aspirin

A photo of five beagle puppies.

Fauci Blasted Over Puppy Research Claims

Conservative watchdog group unleashes outrage over Beagle studies

The cover art for this Anthony Fauci documentary.

New Fauci Documentary: 'You Don't Get Intimidated'

Anthony Fauci gets personal in new film, opens up about Trump admin and history repeating

An infant in the neonatal ICU on a ventilator and connected to various monitors.

Which Pediatric Research Is Overfunded by NIH?

And which conditions are underfunded, and why

A male nurse gives a teen male a COVID-19 vaccination, both are wearing protective masks.

CDC's All-or-Nothing Approach to Teen COVID Vaccination Is All Wrong

The agency should revisit its latest guidance to maximize benefits and minimize risks

Do 'Robots' Offer Any Clear Surgical Advantage?

Review says no, and Vinay Prasad believes it's a sobering reflection on medical technology

Breast Cancer Screening During COVID Reveals Inequities

Vinay Prasad, MD, MPH, discusses new findings and his takeaway

A COVID-19 vaccine in intranasal form in front of several out of focus vials of COVID-19 vaccine.

Nasal Vaccines for COVID-19?

Some argue intranasal vaccines, still in early trials, may be better at blocking transmission

A photo of Lisa Stockman Mauriello next to her dog and holding a sign which reads DON鈥橳 WANT TO DIE

ALS 'Compassionate Use' Again Hits National Media

Expanded access campaigns will only become more frequent with growing rare disease pipelines

Could a 'Placebo' Become the Next Big ED Treatment?

Over-the-counter gel, said to spur near-instant erections, is on the cusp of approval in Europe

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

No Murder Charge in Alleged Mercy Killing; Anti-Vaxxers Gain New Allies; COVID-21?

This past week in healthcare investigations

A man in pain with his hand over a glowing computer rendering of his intestines

Minimizing the Pesky Placebo Response in IBS Trials

Identifying the determinants is key to better trial design

What to Make of That Danish Reinfection Study?

Vinay Prasad, MD, MPH, discusses the findings and their takeaway

The YouTube video thumbnail with The Rock and Rohin Francis, MBB with the words: THE ROCK VS THE DOC

Pseudoscience Royal Rumble: Doc vs The Rock

Celebs who tout "harmless" quack therapies may still be doing harm

Self-Unblinding Threatens COVID Vaccine Trial

Taking antibody tests a 'small act of scientific sabotage'

CROI over a computer rendering of a virus entering a cell membrane

Do HIV Drug Trials Need Better Infection Tests?

Data from PrEP study reveal a sensitivity problem

AAAAI over a computer rendering of antibodies attacking a virus

Minority Participation in Food Allergy Trials Remains Low

Increasing participation is a significant unmet challenge, researcher says

A rainbow tinted photo of three people wearing one piece body suits

Brain Imaging Study Paused After LGBTQ+ Advocates Complain

Concerns that UCLA research could damage participants' mental health

FDA ADCOMM Lutonix 014 Drug Coated Balloon PTA catheter over a computer rendering of a drug coated balloon

FDA Advisors Pan Drug-Coated Balloon for Lower-Leg Ischemia

Panel members cite muddy efficacy data

pembrolizumab (Keytruda) over a close up of a pink breast cancer ribbon pinned to a woman鈥檚 tank top above FDA ODAC

Has Pembrolizumab Finally Met an Indication FDA Doesn't Like?

Agency staff skeptical of data in early breast cancer

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