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Clinical Trials

Slippery Slope: Diet Drugs No Help for Heart

In another edition of the Slippery Slope series examining use of surrogate endpoints in drug approvals, 51成人动漫 and the Milwaukee Journal Sentinel find diet drugs are approved without solid evidence of benefits, but with hints of harm.

Brain Cancer: Did '60 Minutes' Report Raise False Hope?

Glioblastoma virotherapy touted on CBS program is promising but preliminary.

The NNT: An Overhyped and Confusing Statistic

Some pitfalls of summing up evidence with Numbers Needed to Treat.

FDA Advisers Unimpressed by Nocdurna

Another setback for nocturia indication

Droxidopa for OH Slammed by FDA Reviewers

SILVER SPRING, Md. -- Droxidopa (Northera) is getting a second look by an FDA advisory committee for the treatment of orthostatic hypotension stemming from neurological disorders like Parkinson's disease, but an agency review doesn't look promising for approval.

MoCA Beats MMSE to Assess Dementia

NEW ORLEANS -- The Montreal Cognitive Assessment (MoCA) was better than the Mini-Mental State Examination (MMSE) at teasing out subtle differences in cognitive performance among mildly impaired individuals, researchers reported here.

Striking a Nerve: MS Cured With an OTC Drug?

A neurology researcher is planning a clinical trial of a widely available drug that he thinks could stave off disability in multiple sclerosis patients. How much should he (or we) say publicly about it?

FDA Panel Vetoes New Tolvaptan Indication

SILVER SPRING, Md. -- An FDA advisory committee has declined to endorse an expanded indication for tolvaptan (Samsca) to treat autosomal dominant polycystic kidney disease.

Sildenafil Trial Halted in Patients with Sickle Cell Disease

LITTLE FALLS, N.J. -- The National Heart, Lung, and Blood Institute has halted a trial of sildenafil (Revatio) in sickle cell patients with pulmonary hypertension because of increased hospitalizations for sickle cell crises, or severe pain, the agency said.

GAO Sting Shows Independent Review Boards Are Vulnerable to Fraud

WASHINGTON -- Institutional review boards (IRBs) may not provide the clinical trial safety net they were designed to be, a federal investigation revealed.

Weight-Loss Trial Final Report: 52 Pounds of Fat Melted Away

WEST PALM BEACH, Fla. -- The official results are in: My ending weight was 231 pounds -- a loss of 52 pounds from my starting weight of 283 pounds in January 2008.