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Clinical Essentials

About Thyroid Eye Disease

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Predicting Outcomes in Graves’ Orbitopathy

Researchers in Korea recently identified predictive factors for normalization of thyroid-stimulating immunoglobulin levels in moderate-to-severe Graves’ orbitopathy, highlighting the importance of early treatment.

In Thyroid-Associated Orbitopathy, Using Smartphones to Assess Disease Activity

A smartphone-based machine learning-assisted system for evaluating clinical activity in thyroid-associated orbitopathy may represent a promising new approach to the diagnosis and management of this condition.

Asymmetry in Thyroid Eye Disease: Prevalence and Characteristics

Asymmetric disease may occur in one-third of patients with thyroid eye disease, with muscle volume expansion possibly contributing to the asymmetry. A standardized definition of asymmetry using more objective parameters is needed to facilitate comparisons among studies.

Thyroid Eye Disease: Is There a Biomarker for Muscle Enlargement?

Investigators retrospectively reviewed medical records of patients with thyroid eye disease to determine the most useful biomarker for extraocular muscle enlargement.

Graves’ Orbitopathy in Thyroid Cancer: Beware Higher Doses of Radioactive Iodine

A South Korean study followed patients with thyroid cancer to assess for risk of Graves’ orbitopathy, finding an association with radioactive iodine treatment.
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In Thyroid Eye Disease, Could This Be a Novel Target?

According to a study from Mayo Clinic, pregnancy-associated plasma protein A has a role in the pathogenesis of thyroid eye disease and may be a more selective target for novel therapies modulating insulin-like growth factor activity, the main driver of TED.