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News, opinions and meeting coverage in primary care.

A graphic from the American Heart Association of Life鈥檚 Simple 7.

Even With High Genetic Risk for Alzheimer's, Lifestyle Factors Matter

Midlife scores on Life's Simple 7 tied to dementia incidence across a range of genetic profiles

A photo of a person鈥檚 foot with gout.

Is Gout Protective Against Dementia?

Provocative results from Korean study

ATS over a photo of the San Francisco Marriott in San Francisco, CA

Triple Therapy for COPD: One Drug Too Many, Too Often?

Dropping the inhaled steroid seems to help many patients in real-world study

A computer rendering of three trees shaped like human heads progressively losing their leaves

Dementia Risk Factors Vary By Age

Vascular factors at age 55 are different from those later in life

AACE over a photo of the Hilton San Diego Bayfront in San Diego, CA

Tymlos Boosts Bone Health in Men With Osteoporosis

Daily agent upped bone mineral density at multiple sites in phase III ATOM trial

A photo of a senior man eating a hot dog at a country fair.

Brain Aging Markers Tied to Inflammatory Foods

Smaller brain volume seen with diet-driven inflammation

A portrait of a senior man in a hospital bed.

Laughing in the Face of Death

Only the rare patient has a sense of humor at the end of life

FDA APPROVED Lumipulse G 尾-Amyloid Ratio (1-42/1-40) test over a computer rendering of amyloid plaques around neurons.

Early Alzheimer's Test Gets FDA Nod

First in vitro diagnostic to detect amyloid in early disease setting

A close up of a mature man receiving an injection in his arm by a healthcare professional.

Another Link Between Prostate Cancer Hormone Tx and Impaired Cognition

Strongest association with enzalutamide, but survival benefit outweighs effect, specialists say

A close up of a healthcare worker drawing blood from a senior鈥檚 arm.

How Often Does Prediabetes in Seniors Escalate to Full-Blown Disease?

Study finds estimated annual progression rate to diabetes of 5.3%

A photo of a senior woman holding a glass of water and a white pill.

Could NSAIDs Negate Bisphosphonate Benefits?

Women taking clodronate and NSAIDs didn't see a protective effect

An indoor shot of the foot of a cane next to a man鈥檚 bare feet on a wood floor.

Home Walking Program Eases Peripheral Artery Disease Limitations

Randomized trial shows modest impact even without in-facility supervision

A close up of a woman鈥檚 hand gnarled by arthritis resting on the head of a cane.

Is Alzheimer's Risk Lower With TNF Inhibitors?

For arthritis patients with cardiovascular disease, the answer may be yes

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Polypill Looks Good for Parkinson's

Fixed-dose product combining two standard drugs outperforms each alone in phase III

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Prion Disease on the Rise in the U.S.

Now the question is, why?

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Could Undiagnosed Neuro Condition Explain Grandpa's Falls?

Peripheral neuropathy found in many patients who weren't aware of it

FDA APPROVED testosterone undecanoate (TLANDO) over a man holding a white pill between his fingers and a glass of water.

Another Oral Testosterone Undecanoate OK'd for Hypogonadism

FDA approval of Tlando follows in the footsteps of Jatenzo

A photo of the vials and packaging of Iron Dextran Injection, USP

Pumping (IV) Iron Linked to Varying Anaphylaxis Risk for Older Adults

Study finds risk was low, but unequal across different products

A photo of a senior woman in a wheelchair holding her knee; both knees have scars from knee replacement surgery.

'It's an Alien Knee in There': Mixed Feelings After Joint Replacement

Study highlights common, but rarely discussed, problem

A photo of the vial and packaging of Aduhelm.

Aducanumab Data Finally Published, but Alzheimer's Experts Spot Problems

Questions raised about secondary endpoints

An ophthalmologist measures the intraocular pressure of a patient鈥檚 eye using a tonometer.

Glaucoma: The Newest Autoimmune Disease?

Researchers argue for a "paradigm shift"

A computer rendering of a syringe and the the knee joint of a skeleton.

Reassurance on Steroid Shots for Knee OA

Study counters fears that injections worsen underlying pathology

A senior woman sitting in bed massages her toes.

Peripheral Nerve Problems Tied to Later Dementia

Findings may indicate shared susceptibility to neurodegeneration

Medical staff members from Jiangsu Province work at an ICU ward of the First Hospital of Wuhan City in Wuhan, central China

Cognitive Effects Persist in Older COVID Patients

Long-term cognitive decline common after SARS-CoV-2 hospitalization

An x-ray image of knees affected by osteoarthritis.

Hopes Dashed for Novel Osteoarthritis Treatment

Noninvasive therapy looked like a sure winner until trial results came in

A portrait of a mature man cupping his ear with his hand in an effort to hear.

Hearing Loss, Epilepsy May Be Early Signs of Parkinson's Disease

Known symptoms like tremor spotted in primary care records 10 years before diagnosis

A photo of a prescription bottle on its side spilling out white pills next to a blood pressure monitor.

ARB-Cancer Link May Come Down to Cumulative Exposure

Does a new paper resolve the conflicting safety data on the popular antihypertensives?

A photo of a senior woman in a wheelchair in a nursing home hallway.

Biden Administration Announces Steps to Improve Nursing Home Care

Measures include those aimed at increasing staffing and cutting down on unnecessary treatment

A photo of an effervescent tablet in water releasing bubbles.

Salt in Fizzy Tablets Linked to Heart, Death Risk

Warning signals seen for fast-acting acetaminophen and other drugs

A portrait of a mature bearded man with a tabby cat draped over his shoulder.

Owning a Pet May Protect Cognitive Health

Strongest benefit seen for long-term pet owners

A close up of a woman鈥檚 hand on an automatic blood pressure monitor

Non-Validated BP Monitors Are a Global Problem

Thousands of device models don't meet international standards

A senior man sits in a chair next to his bed and looks out the window.

Loneliness May Triple Dementia Risk

Even without dementia, lonely feelings linked with brain changes

A close up of a senior grandmother grasping her granddaughters hands

Mystery: Why Would Hand OA Be Less Severe in Black People?

Data contrast with previous findings for hip and knee osteoarthritis

STS over a photo of a surgeon performing a thoracic operation using a fiber optic head-light.

More Evidence for Prehab Before Cardiac Surgery

One center's initial experience suggests good perioperative results

A blue rubber gloved hand holds a test tube of blood in front of a brain MRI

Blood Biomarkers May Distinguish Dementia Disorders

Plasma levels show diagnostic, prognostic performance in varying dementia types

A blood pressure cuff, a stethoscope and a spilled prescription bottle of green pills.

Mixing and Matching BP Meds? Consider the Implications for Dementia

SPRINT analysis favors certain classes of antihypertensives

Strawberries, blueberries, grapes, red wine corks, and a bottle of balsamic vinegar

More Flavonoids, Better Parkinson's Outcome

Flavan-3-ols and anthocyanins consistently linked to lower mortality

A box of BinaxNOW rapid tests next to other products in a medicine cabinet in a home.

Medicare Patients Can't Get Their At-Home COVID Test Kits Covered -- Yet

But CMS says it's working to provide that coverage

The packaging and blister pack of Cymbalta

Muddled Picture for Antidepressant as Osteoarthritis Pain Reliever

Trial in primary care setting fails to confirm benefit seen in specialty clinics

An illustration depicting Alzheimer鈥檚 disease with amyloid plaques forming between neurons

Alzheimer's Drugs Race to FDA

After aducanumab, drug companies pivot to use the accelerated approval pathway

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