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General Neurology

News, opinions and meeting coverage in neurology.

Women on Seizure Meds Need More Folic Acid

WASHINGTON -- About half of epileptic women taking anti-seizure drugs who could have become pregnant said they were not taking the recommended folic acid supplements, results of a survey found.

At-Home Seizure Tests Promising

WASHINGTON -- Technologies to provide instant at-home detection of life-threatening seizures and that could allow epilepsy patients to monitor their own drug levels are almost ready, researchers said here.

Satisfaction With Epilepsy Surgery Lasts Long Term

WASHINGTON -- More than 90% of patients who had surgery for drug-resistant epilepsy said it was worthwhile when interviewed up to 20 years later, even when quality-of-life indicators were not improved, researchers said here.

Laser Epilepsy Surgery Boosts Memory Function

WASHINGTON -- Stereotactic laser ablation of seizure foci in the hippocampus appeared to reverse certain types of memory deficits that commonly occur in this population, researchers said here.

ADHD: Brain Iron May Be Marker

CHICAGO -- Low Fe levels in the brain may signal the presence of attention-deficit/hyperactivity disorder (ADHD), researchers reported here.

Magnet Therapy Cuts Binge-Purge Eating

SAN DIEGO -- A course of transcranial magnetic stimulation (TMS) helped about half of patients with binge/purge eating disorders to cut the frequency of such episodes significantly, a researcher said here.

Brain Stimulation Helps Smokers Quit

SAN DIEGO -- Magnetic brain stimulation with a sensory cue was associated with reduced smoking rates and improved quit rates among heavy smokers unaffected by prior therapy, researchers reported here.

Teens More Apt to Fight Than Flee

SAN DIEGO -- Teens were more likely to actively respond to aggressive cues than were children or adults, researchers reported here.

Exercise May Allay Anxiety, Depression

SAN DIEGO -- Exercise may have modest benefits as a treatment for patients suffering from anxiety or depression, researchers reported here.

Gestational Diabetes Tied to Perinatal Stroke

AUSTIN, Texas -- Perinatal arterial ischemic stroke has many possible risk factors, including gestational diabetes, researchers reported here.

Stem Cells Help ALD Kids Live Longer

AUSTIN, Texas -- Survival in children with cerebral adrenocerebral adrenoleukodystrophy (ALD) appeared to be improved with allogeneic hematopoietic cell transplants compared with untreated patients, a researcher said here.

NICU Survivors May See Higher Autism Rates

AUSTIN, Texas -- Autism spectrum disorder incidence was significantly higher in babies who spent time in the neonatal intensive care unit, versus the general population, and was often accompanied by comorbidities, researchers said here.

Mom's Lupus Tied to Child's Autism

SAN DIEGO -- Children born to mothers with systemic lupus erythematosus have twice the risk for autism spectrum disorders as those whose mothers are unaffected, a Canadian researcher reported here.

Striking a Nerve: Heinz Kerry Recovers

Teresa Heinz Kerry is back at work less than 4 months after a mysterious seizure hospitalized her. Striking a Nerve is a blog by John Gever for readers interested in neurology.

Sleep Problems, Poor Angioplasty Outcomes Linked

Disturbed sleep is common in heart patients following coronary angioplasty and is an independent risk factor for poor cardiac outcomes, researchers reported.

Common Cause for Bruxism, Restless Legs, Migraine?

NEW ORLEANS -- About half of patients with restless legs syndrome (RLS) seen in a single neurology practice also qualified for diagnoses of bruxism and migraine, suggesting a possible common cause for these disorders, a researcher said here.

Heart Surgery as Infant Hikes Risk for ADHD Later

Children who underwent surgery for congenital heart disease in the first year of life appeared to carry an increased risk of attention deficit hyperactivity disorder (ADHD) once they reached school age, researchers found.

MoCA Beats MMSE to Assess Dementia

NEW ORLEANS -- The Montreal Cognitive Assessment (MoCA) was better than the Mini-Mental State Examination (MMSE) at teasing out subtle differences in cognitive performance among mildly impaired individuals, researchers reported here.

Xyrem Helps With Nighttime Sleep in Narcolepsy

NEW ORLEANS -- Narcolepsy patients troubled by frequent nighttime awakenings had less sleep disruption when taking sodium oxybate (Xyrem) than modafinil (Provigil) in a randomized trial, a researcher reported here.

Striking a Nerve: MS Cured With an OTC Drug?

A neurology researcher is planning a clinical trial of a widely available drug that he thinks could stave off disability in multiple sclerosis patients. How much should he (or we) say publicly about it?

Opioid Use Common After Spine Surgery

NEW ORLEANS -- One year after surgery to relieve back pain, about of third of patients still were using narcotic painkillers, according to a study that raised new concerns about the long-term use of opioids.

Data Supports Eslicarbazepine in Epilepsy

VIENNA -- Pooled phase III study results on eslicarbazepine acetate, a prodrug for S(+)-liscarbazepine, showed that the drug outperformed placebo as add-on therapy for partial-onset seizures in adults, a researcher said here.

N.H. Hospital May Have Exposed Patients to CJD

Health officials in New Hampshire said eight neurosurgery patients at one hospital in the state may have been unwittingly exposed to Creutzfeldt-Jakob disease (CJD).

FDA Adds Black Box Warning to Malaria Drug

The FDA has added a boxed warning to the labeling of the antimalarial drug mefloquine, advising of the possibility of neurologic and psychiatric adverse events, the agency announced.

Hangover Risk Prompts Ambien Label Changes

New dosing recommendations for products containing zolpidem (Ambien, Ambien CR, Edluar) are now included in their labels, along with warnings of next-day hangover effects, the FDA said Tuesday.

FDA Allows Opana Generics

The original formulation of extended-release oxymorphone (Opana ER) that lacked abuse-resistant mechanisms was not pulled from the market for safety reasons, and therefore generics based on that recipe are permissible, the FDA said.

Triptans Go-To Migraine Drugs Even in Pregnancy

The triptans, most experts agree, are the go-to drugs for frequent or serious migraines in pregnancy.

On-Call Pay Varies Widely by Specialty

Surgeons commanded more than $1,000 a day for being on-call at the hospital, while primary care physicians reported compensation rates of around $150 a day, according to annually compiled data.

Lyme Disease, Autism Link Debunked

A new study has found no evidence of an association between Lyme disease and autism.

AAN: Anxiety Drug May Help in Autism

SAN DIEGO -- The hypertension and anxiety treatment propranolol improved general social functioning in young adults with autism spectrum disorder, researchers reported here.

PML Not Fatal if Caught Early

SAN DIEGO - All multiple sclerosis patients taking natalizumab (Tysabri) who were diagnosed with a serious condition called PML before symptoms appeared were still alive a year later, researchers said.

ECG for Eyes Sorts Strokes from Vertigo

A device described as an ECG for the eye accurately distinguishes stroke from other causes of dizziness in the emergency department, a small proof-of-concept study showed.

Deaths Trigger DEA Probe of Pain Specialist

Treating pain is challenging, and sometimes perilous, for both physician and patient, as is illustrated by Lynn Webster, MD, president-elect of the American Academy of Pain Medicine, who is the subject of an investigation triggered by as many as 20 deaths among his patients.

FDA: Booze and Xyrem Are Dangerous Mix

WASHINGTON -- The FDA is warning healthcare professionals that patients taking the muscle weakness and narcolepsy drug sodium oxybate (Xyrem) should not consume alcohol or use central nervous system depressants.

ALS Drug Gets Review for VA Coverage

LAS VEGAS -- Riluzole (Rilutek) should remain on the Veterans Administration formulary as a treatment for patients with amyotrophic lateral sclerosis, despite having only modest benefits and considerable cost, a researcher said here.

Injector Pen May Ease Emergency Seizure Tx

SAN DIEGO -- An investigational pen-type injector for delivering intramuscular diazepam appeared safe and effective for home treatment of acute seizures, researchers said here.

Climbers Face Lasting Effects if Brain Swells

CHICAGO -- Extreme mountaineers who develop serious brain swelling at altitude appear to have lasting evidence of small hemorrhages in their brains, researchers said here.

Early Stroke Risk After Hip Replacement

Patients undergoing a total hip replacement appear to have an elevated risk of stroke in the weeks following the operation, researchers found.

Meningitis: FDA Warns of 'Light Therapy' Claims

A Tennessee company made false claims that its "light therapy" has benefits for fungal meningitis, the FDA said.

AHA: No Excess Bleeding Risk with Dabigatran

LOS ANGELES -- Patients starting dabigatran (Pradaxa) did not have a higher risk of bleeding compared with new users of warfarin, according to a postmarketing data review by the FDA.

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