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General Neurology

News, opinions and meeting coverage in neurology.

Mild Stenosis Linked to Death in Diabetes

Long-term registry shows impact similar to single-vessel obstruction.

Atherosclerosis a Signal for Brain Drain?

Plaque burden was linked to cognitive impairment in a population-based study.

Gout May Protect Against Alzheimer's Disease

Study showed AD incidence higher over 5 years for patients without gout.

That's Not Chronic Lyme, It's Cancer

Three case reports demonstrate the risks of "assuming that patients have chronic Lyme disease."

Portenoy Opioid Talk Sparks Controversy

Opioid advocate Russell Portenoy's invitation to an upcoming NIH workshop is under fire.

TCT: PFO No Panacea for Migraine

WASHINGTON -- Percutaneous patent foramen ovale (PFO) closure did not significantly reduce the number of monthly migraine days compared with medical treatment, researchers reported here.

Multiple Sclerosis Risk Tied to Some OCs

BOSTON -- Women using combined oral contraceptives containing norethindrone or levonorgestrel were substantially more likely to develop multiple sclerosis than those not on "The Pill."

Generic Copaxone for MS Passes Clinical Test

BOSTON -- A copycat version of the multiple sclerosis drug Copaxone, known generically as glatiramer acetate, performed similarly to the original product in a head-to-head trial, paving the way for it to win regulatory approval as a generic drug.

Novel Drug Beats Avonex for MS Efficacy; Safety Still a Worry

BOSTON -- Daclizumab HYP cut relapse rates and disability progression in multiple sclerosis patients more effectively than interferon beta-1a (Avonex) in a phase III trial, but liver toxicity with the IL-2 inhibitor reared its head again.

'Sleep Drunkenness' Common, But Rarely Unexplained

So-called confusional arousals were reported in the past year by some 15% of respondents in a population-based survey, with nearly all episodes associated with mental disorders or drugs with known sleep effects.

Wait, What? Medium Was Accurate, Says Peer-Reviewed Study

Sometimes, blog posts write themselves. Others are written by dead doctors with the help of a medium.

HIV Drug Cleared of Cognition Hit

MELBOURNE, Australia -- Although it has well-known psychiatric side effects, the HIV drug efavirenz (Sustiva) does not affect cognition, a researcher said here.

HTN May Halt Dementia in Very Elderly

COPENHAGEN -- Among individuals who developed hypertension at age 90 or later, their risk of also developing dementia was dramatically lower than other very elderly people whose blood pressure remained normal.

Codpieces a Cover for Syphilis? That's Improbable!

A weekly report from our friends at Improbable Research.

AMA Highlights: VA, Cheerleaders, and Guns

CHICAGO -- Wrapping up a full agenda, the AMA agrees cheerleading is a sport, doctors outside the VA need to pitch in to help care for veterans, and e-cigarettes need to be regulated.

AMA Clamps Down on MOC, But Punts on Gun Regs

CHICAGO -- The AMA鈥檚 House of Delegates drew the line on this year's hot button topic -- maintenance of certification (MOC), saying it should not be mandatory, nor should it be a condition of licensure.

Dalfampridine: Not Just a Walking Aid

DALLAS -- Extended-release dalfampridine (Ampyra) is approved for boosting walking speed in multiple sclerosis patients, but its benefits extend to other aspects of physical function, according to a small study reported here.

CCSVI Practices Suboptimal but Patients Don't Mind

DALLAS -- Canadian multiple sclerosis patients who left the country to undergo the controversial procedure called chronic cerebrospinal venous insufficiency (CCSVI) often received poor pre- and postoperative care, but most were still relatively satisfied overall, a researcher reported here.

Gastro Effects Dog Oral MS Drug Tecfidera

DALLAS -- Large proportions of patients starting on dimethyl fumarate (Tecfidera) for multiple sclerosis need additional medications to manage the drug's GI and other side effects, and a substantial minority ultimately find the drug intolerable.

MS Bladder Problems Show Up Early and Often

Nearly 80% of multiple sclerosis patients in a large registry reported overactive bladder symptoms, and one-third of a separate cohort of newly diagnosed patients also showed urinary dysfunction, researchers reported here.

War Wounds: Hearing Loss Tracks Gulf War Vets

Battlefield wounds are often both life-threatening and life-changing, but when hearing is the casualty, the wound is too often undiagnosed or untreated, but a new initiative is underway to change tackle the silent wounds of war.

Medtronic's Infuse Moves From Operating Room to Courtroom

An investigative series by 51成人动漫/Milwaukee Journal Sentinel has been tracking the spinal fusion device called Infuse in a 4-year-long series and now reports how a flawed FDA system for device approval may have led to a long string of adverse events culminating in thousands of liability suits.

FDA Slashes Starting Dose for Lunesta

SILVER SPRING, Md. -- Patients starting on the sleep drug eszopiclone (Lunesta) should take no more than 1 mg at bedtime -- one-third the current label-recommended dose -- because of the risk of next-day impairment, the FDA said Thursday.

Shingle Risk High in Lupus, RA, COPD

Patients with autoimmune diseases and certain other chronic conditions are at increased risk for herpes zoster, a U.K. case-control study found.

Patients鈥� Eye Color a Clue to Pain Tolerance

TAMPA -- Caucasian women with light-colored eyes -- blue or green -- appear to tolerate pain better than Causcasian women with brown or hazel eyes, researchers reported here.

Humans Beat Stroke Scales for ICH Prognosis

PHILADELPHIA -- Physicians and nurses in stroke units more accurately predicted outcomes in patients with intracerebral hemorrhage (ICH) compared with common prognostic scales, a researcher reported here.

'Sensory Tricks' in Dystonia Examined

PHILADELPHIA -- The mystery of how "sensory tricks" adopted by patients to relieve symptoms of dystonia work is beginning to be unraveled, research presented here suggested.

APA Meeting Highlights Mental Health Biology

NEW YORK CITY -- The biological basis for normal and abnormal mental function is emerging as a dominant theme in psychiatry research, and the American Psychiatric Association annual meeting that starts here Saturday won't be an exception.

Environmental Factors Tied to Autism Clusters

An analysis of an insurance claims database of 100 million patients has found clustering of autism spectrum disorder and intellectual disability in counties across the U.S.

Stroke Rounds: Early Surgery Looks Safe After tPA

Performing carotid endarterectomy or stenting in patients who were recently treated with thrombolytic therapy for an acute stroke appeared to be safe, an observational study showed.

Medtronic Sued by 1,000 Infuse Patients

Medtronic said about 1,000 people have sued the company over its bone morphogenetic protein-2 product, Infuse, and that many more lawsuits may be coming.

Killing Pain: Xanax Tops Charts

Alprazolam, more popularly known by its brand name -- Xanax--is America's favorite tranquilizer and one that is often used in combination with an opioid.

FDA OKs Northera for Hypotension

The FDA has approved droxidopa (Northera) for the treatment of neurogenic orthostatic hypotension, a rare disease that results in a drop in blood pressure when patients try to stand up.

Lyrica Edges Mirapex for Restless Legs

Patients with restless legs syndrome treated with pregabalin (Lyrica) had as much symptom improvement as those receiving pramipexole (Mirapex) in a large year-long trial, with fewer showing "augmentation."

Is There a Flaw in This Large Vitamin D Trial?

A co-principal investigator of the VITAL trial addresses the possibility that out-of-study testing of vitamin D levels and initiation of high-dose supplementation could be a limitation, but not a serious one.

CardioBuzz: More Money Needed for Heart Research?

The NIH dedicates a lot of money for research into heart disease and stroke, but it still might not be enough, a new study suggested.

Pay and Practice: Are Neurologists Primary Care Docs?

WASHINGTON -- Neurology isn't often mentioned in the same breath as primary care, but the American Academy of Neurology is again lobbying to gain that sobriquet -- this time to take advantage of a recent policy change that benefits primary care providers.

Droxidopa for OH Slammed by FDA Reviewers

SILVER SPRING, Md. -- Droxidopa (Northera) is getting a second look by an FDA advisory committee for the treatment of orthostatic hypotension stemming from neurological disorders like Parkinson's disease, but an agency review doesn't look promising for approval.

Killing Pain: Tramadol the 'Safe' Drug of Abuse

Almost 2 decades have passed since the FDA approved tramadol as a 'safe' opioid, but the intervening years provide evidence to question that 'safe' claim, as this latest investigation by John Fauber for the Milwaukee Journal Sentinel-51成人动漫 revealed.

Neuropathy May Signal Lupus

Peripheral neuropathy is a more common manifestation of systemic lupus erythematosus than has been previously appreciated, and often is a small-fiber neuropathy affecting the dorsal root ganglia, a large retrospective study found.

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