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General Neurology

News, opinions and meeting coverage in neurology.

ECTRIMS over a photo of the Milano Convention Center in Milano Congressi, Italy.

Neurofilament Light Predicts MS Worsening in Silent Progression

NfL changes occurred in advance of, not coincident with, clinical worsening

ECTRIMS over a photo of the Milano Convention Center in Milano Congressi, Italy.

Subcutaneous Ocrelizumab Not Inferior to IV Infusion

Both provided rapid B-cell depletion

A computer rendering of a roundworm.

The Parasite Heard 'Round the World

A wriggling worm in a woman's brain underscores parasites' indomitable will to survive

ECTRIMS over a photo of the Milano Convention Center in Milano Congressi, Italy.

Novel Drug Shows Promise in Multiple Sclerosis

CD40 ligand inhibitor leads to sustained reduction of MRI disease activity

An MRI image of skull damage in a patient with a traumatic brain injury

Brain Death Guidelines Revised

New recommendations address hypothermia, ECMO, pregnancy

A photo of a box of Tamoxifen tablets.

Tamoxifen Fails to Deliver on Clinical Promise for Duchenne Muscular Dystrophy

Phase III trial finds that repurposed tamoxifen was safe but ineffective

A photo of a person using a stick welder.

Parkinsonism Case Tied to Welding, Improved With Chelation

How one team pinpointed manganese toxicity and diminished a patient's motor symptoms

A photo of a mature woman suffering from a headache and sitting on a couch with her eyes closed and hand on her head

COVID Vaccine, Infection May Affect Migraine Course Slightly

Researchers compared headache diary data before and after vaccination or infection

Neuro Break over a computer rendering of neurons.

Chronic Stress and Dementia; Hormones and Brain Health; Dementia Protection Neurons?

News and commentary from the world of neurology and neuroscience

A photo of a mature woman holding a cup of tea with both hands at home.

Loneliness Tied to Subsequent Parkinson's Risk

Findings support Surgeon General's recent call to improve social connection

FDA APPROVED cipaglucosidase alfa (Pombiliti) plus miglustat (Opfolda) over a muscle biopsy showing accumulation of glycogen.

New Option OK'd for Pompe Disease

FDA approves two-component therapy for patients not improving on enzyme replacement therapy

FDA ADCOMM debamestrocel (NurOwn) over a computer rendering of a damaged neuron.

FDA Panel Overwhelmingly Rejects ALS Cell Therapy

Echoing concerns from agency reviewers, advisors can't find evidence of efficacy

Neuro Break over a computer rendering of neurons.

Theory Slammed as Pseudoscience; TBI and Cardiovascular Risk; AAN Shares Its Vision

News and commentary from the world of neurology and neuroscience

FDA ADCOMM debamestrocel (NurOwn) over a computer rendering of a damaged neuron.

FDA Staff Voice Serious Concerns About Investigational ALS Cell Therapy

Data are "scientifically incomplete" and manufacturing info is "grossly deficient"

A close up photo of a blood draw.

Long COVID Blood Tests Show Distinct Immune and Hormone Function

Algorithm may help predict who gets long COVID

A computer rendering of Lewy bodies inside a nerve cell.

Blood, CSF Marker Detects Parkinsonian Disorders

Enzyme also identified preclinical Lewy body disease

Neuro Break over a computer rendering of neurons.

Acrylic Window to the Brain; Chronic Fatigue Discovery; AI Spots Parkinson's Risk

News and commentary from the world of neurology and neuroscience

A photo of vehicles on a highway.

Many Medicare Patients Travel 50-Plus Miles for Neurology Visits

Telemedicine can improve access to care, researchers argue

A photo of a surgeon performing a mechanical thrombectomy

Stroke Doesn't Have to Lead to Death or Disability

Rapid, appropriate treatment can save lives and limit severe outcomes

A computer rendering of the dorsal striatum and lateral ventricles in Huntington鈥檚 disease

Huntington's Disease More Severe in Black Patients at Baseline

Outreach to families of minority patients may help identify genetic disorder

A photo of a mature man laying on his couch and holding a remote.

Dementia Risk Tied to Sedentary Lifestyle

Ten hours or more a day of sedentary behavior raised risk of incident dementia

Neuro Break over a computer rendering of neurons.

Telomeres and Dementia; Cell Therapy and Parkinson's; Next Up: In Utero Neurology

News and commentary from the world of neurology and neuroscience

A photo of a vial of Ultomiris over a computer rendering of the degradation of motor neurons

Ravulizumab Showed Preclinical Promise for ALS. What Happened?

Phase III trial terminated for futility

A photo of Stephen Hauser, MD, next to the cover of his book The Face Laughs While the Brain Cries.

The Quest to Solve MS: 'It's a Story That's Optimistic'

Stephen Hauser, MD, talks about The Face Laughs While the Brain Cries

A photo of a healthcare worker drawing blood from an infant.

Rapid Genome Sequencing in Infants With Epilepsy Shows Immediate Benefit

Pilot study suggests early testing for seizures, regardless of treatment setting

A photo of senior male twins playing cards.

Twin Study Ties Cognitive Decline With Earlier Traumatic Brain Injuries

Twins with TBI at age 25 or older had sharper drops in cognition as they aged

A photo of Mitch McConnell

Sen. McConnell Reminds Us That 'Just a Fall' Can Lead to So Much More

Falls should not be taken lightly, especially in older adults

A photo of a woman holding the hand of a man covered with a sheet in a hospital bed.

Deciding Who Is Dead: Physician Group Issues New Statement

American College of Physicians adds to debate about redefining death

Predicting ICU Outcomes; Post-Stroke Brain Stimulation

Also in TTHealthWatch: effect of frailty on intensive blood pressure control

A computer rendering of covid viruses.

Post-COVID Cognitive Deficits Linked With Clotting Proteins

Two blood biomarker profiles predicted cognition 6 and 12 months after infection

An MRI image of the brain and photo of the parasitic roundworm found in the patient.

Live Worm Removed From Woman's Brain

New infection never before documented in humans

Neuro Break over a computer rendering of neurons.

Parkinson's and Plant-Based Diets; AI and Dementia; Why Do Some People Develop ALS?

News and commentary from the world of neurology and neuroscience

A photo of high school football players colliding on the field.

Brain Damage, Including CTE, Seen in Athletes Who Died Young

Cognitive, behavioral symptoms frequent among brain donors under age 30

FDA APPROVED natalizumab-sztn (Tyruko) over a computer rendering of a damaged neuron.

First Multiple Sclerosis Biosimilar Approved

Natalizumab-sztn gets a nod from the FDA

A photo of a mature man sitting on the edge of his bed holding tow different shoes.

Dementia Risk From Midlife Onward Predicted With New Tool

Novel 14-year risk score draws largely on modifiable risk factors

A photo of a woman using a speech-to-text brain-computer interface

Novel Brain Implants Help Paralyzed People Speak Faster, More Accurately

Groundbreaking system helps woman with paralysis communicate through a digital avatar

FDA APPROVED valbenazine (Ingrezza) over a computer rendering of healthy brain and a brain in Huntington鈥檚 disease

Huntington's Disease Chorea Gets New Treatment

Thumbs up for the VMAT2 inhibitor valbenazine, FDA says

A photo of a baby girl standing in front of a television displaying the Peppa Pig cartoon.

Toddlers' Screen Time Linked to Delayed Development

More time on devices at 1 year was associated with specific delays at 2 and 4 years

A photo of a mature woman receiving a brain CT scan.

HIV Patient With Movement Disorder Has Different Symptoms on Left and Right Sides

An unusual manifestation of cerebral toxoplasmosis

A photo of a senior man receiving chemotherapy in an infusion clinic.

Experts Warn on Mixing New Alzheimer's Drug and Antidepressants

Patients starting SSRIs and lecanemab may warrant close monitoring

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