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Duchenne Drug Fails Confirmatory Trial; COVID Brain Changes; First-Seizure Clinics

— News and commentary from the world of neurology and neuroscience

MedpageToday
Neuro Break over a computer rendering of neurons.

Preliminary data showed that viltolarsen (Viltepso), an exon-skipping drug that won accelerated approval to treat Duchenne muscular dystrophy in 2020, , NS Pharma said.

NG2 glia may by inhibiting prostaglandin E2 signaling from microglia to neurons, lab and animal studies suggested. (Nature Neuroscience)

An artificial-intelligence system coupled with a brain implant from a bilingual patient with paralysis into either Spanish or English words. (Nature Biomedical Engineering)

A resting-state functional MRI study in China demonstrated in COVID survivors versus healthy controls. (Lancet Regional Health-Western Pacific)

Multiple sclerosis with combination of the central vein sign, paramagnetic rim lesions, and cortical lesions. (Neurology: Neuroimmunology and Neuroinflammation)

A from the PsychENCODE consortium mapped gene regulation networks in autism, schizophrenia, bipolar disorder, and other conditions. (Science)

Otsuka Pharmaceutical a potential treatment for agitation associated with Alzheimer's dementia, after a phase III trial missed its primary endpoint.

Urolithin A and restored mitophagy and lysosomal functions. (Alzheimer's & Dementia)

And in an Alzheimer's mouse model altered glial activation and amyloid compaction. (Nature Neuroscience)

Progression on the Clinical Dementia Rating scale and cognitive functioning measures would stop driving. (Neurology)

A network meta-analysis supported multimodal interventions for in amyotrophic lateral sclerosis, with an emphasis on exercise. (Scientific Reports)

Patients who attended a in Australia had fewer emergency department visits and hospital admissions, a retrospective study showed. (JAMA Neurology)

  • Judy George covers neurology and neuroscience news for 51˶, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more.