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Oncology/Hematology

News, opinions and meeting coverage in oncology/hematology.

Daratumumab Added to Standard Therapy Improves PFS in Multiple Myeloma

Subcutaneous administration of the anti-CD38 antibody also made for easier dosing

Liso-Cel a Potential New CAR-T Option for High-Risk R/R Follicular Lymphoma

Study results show impressive efficacy, favorable safety profile in the second line

An image of a senior man laying on a hospital bed with an intravenous line attached to his arm.

Futile Immunotherapy for Cancer Grows More Common

Occurs most often at non-academic and low-volume centers

A computer rendering of breast cancer.

Combination Shows Promise in Metastatic ESR1-Mutant Breast Cancer

Durable responses with lasofoxifene plus abemaciclib in post-CDK4/6 inhibitor setting

An x-ray image of a breast cancer lump after surgical removal with a paramagnetic in the middle

Paramagnetic Seeds: An Effective Option for Breast Lesion Localization

Study finds seeds-SPIO combo compares favorably with guidewire-SPIO for breast-conserving surgery

A photo of a glass jar of chemotherapy medication connected to intravenous tubing.

Lessons From the Chemotherapy Shortages: Invest in Generics

We need more sustainable solutions to ensure treatment access

A photo of a nurse administering chemotherapy to a male patient

Cancer Patients Face Frightening Delays in Treatment Approvals

"For them to take weeks -- up to months -- to provide an authorization is ridiculous"

A computer rendering of a ruptured artery leaking blood.

Gene Therapy for Hemophilia Becomes a Reality

Uptake of new options for hemophilia A and B has been a bit slow

Financial Toxicity Among Single Mothers With Metastatic Breast Cancer

Diagnosis coupled with financial burden makes for a difficult situation, but help is out there

Onco Break over a computer rendering of a cancer cell.

Another CAR-T Warning; 'Sweet' Cancer Test; 'Molecular Jackhammer' Blows Up Cancer

News, features, and commentary about cancer-related issues

A photo of a man applying testosterone gel to his shoulder.

Testosterone for Hypogonadism Cleared So Far of Prostate Cancer Risk

No excess high-grade or overall prostate cancer risk in TRAVERSE with 33 months of follow-up

Chemo-Free Quadruplet Promising as Initial Treatment in DLBCL

Approach could allow for a response-adapted reduction of CHOP

A photo of Leonard Bernstein conducting an orchestra.

Mind of the 'Maestro': Inside the Head of Leonard Bernstein

Psychiatrist and concert pianist Richard Kogan, MD, on the great composer's complex inner life

A computer rendering of cytomegaloviruses

Longer Letermovir Prophylaxis Reduced Risk of Cytomegalovirus Infection After HSCT

Randomized study showed extending prophylaxis from 100 to 200 days was effective and safe

A female ear, nose, and throat doctor wearing a headlamp examines her senior male patient.

Significant Left Nasal Obstruction Finally Diagnosed After 2 Years

Nonspecific presentation impedes early diagnosis of rare indolent tumor in older man

Tisa-Cel Yields Durable Responses in R/R Follicular Lymphoma

Our panel of experts discuss 3-year findings from the phase II ELARA study

SABCS 2023 Highlights Open the Door for More Key Data in 2024

Virginia Kaklamani, MD, discusses this year's sessions of interest and looks ahead to next year

Onco Break over a computer rendering of a cancer cell.

Mammo Responsibility Ups Screening; Opioids for Cancer Pain? Ignored Signs of CRC

News, features, and commentary about cancer-related issues

Can JAK Inhibition Help Overcome Lenalidomide Resistance in Myeloma?

Early-phase experience with ruxolitinib suggests potential role in relapsed/refractory disease

A photo of a senior homeless man sitting on a park bench

Homelessness Tied to Worse Cancer Outcomes Among Veterans

However, all-cause mortality rates in lung, colon cancer lower versus other healthcare settings

Responses to Mosunetuzumab in Follicular Lymphoma Remain Durable at 3 Years

Bispecific antibody also shows high response rates in frontline setting

Positive Results for Odronextamab in Relapsed/Refractory DLBCL

But experts aren't sure where it would fit in with currently approved bispecifics

A photo of the word cure in a dictionary.

'Curable': A Case for Precision of Language

Patients need a clear description of their prognosis

A photo of rubber gloved hands trimming a psilocybin mushroom

Psilocybin May Help Ease Depression in Cancer Patients

In small trial, half had early remission of depressive symptoms after psilocybin-assisted therapy

AIBD over a photo of Walt Disney Swan Dolphin Hotel in Orlando, Florida.

National Database Study Finds Higher Risk for Barrett鈥檚 Esophagus in IBD

But no greater chance of BE-tied malignancy for these patients

A photo of a female physician sitting at a desk across from her male patient.

The 'Before and After': An Eye Surgeon's Unexpected Finding

There are a few possible diagnoses in patient with headaches, blurred vision, but one stands out

FDA APPROVED enfortumab vedotin-ejfv (Padcev) + pembrolizumab (Keytruda) over a computer rendering of bladder cancer.

FDA Approves New First-Line Standard of Care in Bladder Cancer

Enfortumab vedotin plus pembrolizumab doubled survival as compared with chemotherapy

A computer rendering of lymphoma cells in the blood

JAK1 Inhibitor Shows 'Remarkable' Activity in T-Cell Lymphoma

Phase II findings on golidocitinib will form the basis of an accelerated approval application

ASH over a photo of San Diego Convention Center.

Hematocrit Stabilized in Polycythemia Vera Treated With Novel Hepcidin Mimetic

Rusfertide maintained hematocrit

A photo of a vial of Tecentriq over a computer rendering of breast cancer.

Atezolizumab Plus Carboplatin Boosts Survival in Metastatic TNBC

But editorialists note that with recent advances, "it is hard to justify" use of combination

FDA approved belzutifan (Welireg) over a computer rendering 0f a tumor on a kidney.

FDA Approves Belzutifan for Advanced Renal Cell Carcinoma

HIF-2 inhibitor indicated for patients who progress after immunotherapy and anti-VEGF

Why Some Myeloma Patients Refuse Stem Cell Transplant

Study shows the various factors behind refusal of autologous stem cell transplantation

'Exploding' Field of Antibody-Drug Conjugates Makes Inroads in Ovarian Cancer

Our panel of experts discuss the latest data from various ongoing trials

Onco Break over a computer rendering of a cancer cell.

Andre Braugher's Cancer Dx; Malignancies Rising in Younger Adults; Negative Trials

News, features, and commentary about cancer-related issues

FDA approved oral eflornithine (Iwilfin) over a computer rendering of a tumor of the adrenal gland.

FDA OKs Maintenance Option for High-Risk Neuroblastoma

Eflornithine approved to reduce relapse risk in both kids and adults

ASH over a photo of San Diego Convention Center.

Ibrutinib-Venetoclax Improves PFS in R/R Mantle Cell Lymphoma

Will results revive ibrutinib role in MCL following withdrawal of accelerated approval?

ASH over a photo of San Diego Convention Center.

'Half-Matched' BMTs Effective in Severe Sickle Cell Disease

High survival rates observed in patients not normally suitable for transplant

A photo of a box of Lenvima capsules over a computer rendering of hepatocellular carcinoma

Lenvatinib-Pembrolizumab Combo Misses Goal in First-Line HCC Trial

Numerical advantages in OS, PFS fall short of statistical significance

ASH over a photo of San Diego Convention Center.

Pomalidomide Cuts Severe Epistaxis in Genetic Bleeding Disorder

24 weeks of daily treatment significantly reduced recurrent nosebleeds in HHT trial

Early Detection Is Key to Higher Cure Rates in Ovarian Cancer

"We are not aware of precancer stages for ovarian cancer"

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