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News, opinions and meeting coverage in cardiology.

ACC: Metformin No Help in MI Recovery

WASHINGTON -- Metformin started soon after reperfusion in the acute setting didn't help cardiac function recover in nondiabetic heart attack patients, a trial showed.

New Guideline Lowers eGFR for Dialysis Start

New Canadian guidelines suggest that nephrologists can wait to start dialysis in some chronic kidney disease patients until their estimated glomerular filtration rate drops below the 10 to 12 mL/min now commonly used.

11 Endocrinology Apps for Docs' Toolboxes

Even if endocrinologists aren't already suggesting smartphone apps to their patients, they've likely been asked to offer up recommendations. Here's a list of 11 apps you should know about.

Diabetes: TAVI Trumps Heart Surgery

Patients with diabetes who had aortic stenosis fared better in terms of mortality and kidney function during the first year if they underwent transcatheter aortic valve implantation (TAVI) rather than surgery, a post-hoc analysis found.

Surgery Beats Medical Tx for Diabetes 'Cure'

ATLANTA -- Bariatric surgery's beneficial effects for type 2 diabetes were significantly greater than even the most rigorous medical and lifestyle interventions, a researcher said here.

Combo Angiotensin Tx Ups Kidney Risks

ATLANTA -- In yet another trial, dual blockade of the renin-angiotensin system (RAAS) didn't slow progression of kidney disease in diabetic patients and carried a higher risk of serious adverse events compared with monotherapy, researchers reported here.

Daytime Snoozing May Tell Risk of Hypoglycemia

Older patients with diabetes who are overly tired during the day may be at a higher risk for hypoglycemia, researchers reported.

In Some Patients Metformin Impairs Thinking

The widely acclaimed diabetes drug metformin was linked with impaired brain function in patients who took the drug, although supplementation with vitamin B12 may alleviate metformin-induced deficiencies, according to new research.

Society Seconds Call for Incretin Data

SAN FRANCISCO -- The Endocrine Society has joined its voice to the recent call for incretin drugmakers to release all patient-level data on their products, the group announced at its annual meeting.

Diabetes Experts Divided About 'Lone Wolf' Butler

Top experts in diabetes and endocrinology have offered mixed reactions to a profile of Peter Butler, MD, chair of endocrinology at the University of California Los Angeles, in the New York Times.

High-Salt Diet May Boost Cortisol

Eating a diet high in sodium increased levels of cortisol and other metabolites, potentially giving rise to metabolic syndrome, researchers found.

Finger Stick Has Promise as Prediabetes Test

PHOENIX -- Measuring capillary blood via finger stick assay was as accurate as venous blood sample assays in predicting 5-year likelihood of diabetes, researchers reported here.

How Much Exercise to Burn Off a Burger?

Menus displaying the amount of exercise required to burn off calories in a meal had some impact on food choice, researchers found.

Cardio Notes: Sex Improves with Stenting

Opening the arteries of those with stable coronary disease also opens the door to an improved sex life. Also this week, bariatric surgery helps remodel the heart.

No Weight Gain with Linagliptin in Diabetes

The DPP-4 inhibitor linagliptin may control type 2 diabetes with less hypoglycemia or weight gain than glimepiride when used as second-line treatment with metformin, a trial showed.

Tattoos Replace Bracelets for Medical Alerts

PHILADELPHIA -- As more people with diabetes replace their medical alert bracelets with tattooed warnings, there might be a need for a standard design and body location, a researcher here said.

Doctors Say 45 Common Tests 'Overused'

Nine specialty groups have listed tests and treatments that are frequently overused, such as antibiotics for sinus attacks and CT scans for low back pain, in the first phase of a long-term project.

FDA Adds More Warnings for Lipitor, Crestor, and Zocor

WASHINGTON -- Statins may cause drug-drug interactions for patients taking drugs to treat HIV/AIDS or hepatitis C, according to a new statin warning from the FDA.

FDA Adds Diabetes Warning to Statin Label

WASHINGTON -- The FDA is changing the labeling on statins to include a warning about increased risks of hyperglycemia and transient memory problems, but the agency is no longer recommending routine liver function testing.

Diabetes Expert Disses Weight-Loss Programs

WASHINGTON -- Community-based weight-loss programs have not been shown to be effective at reducing the incidence of diabetes, so implementing a national program would likely be money down the drain, a diabetes expert said at a symposium on Tuesday.

Fructose No Substitute for Glucose in Diabetes

NEW YORK -- Although it negates the dumping of glucose directly into the bloodstream, fructose may not be the choice sweetener for diabetics, researchers said here.

EASD: Gestational Diabetes Guidelines Controversial

LISBON -- International guidelines on screening for gestational diabetes that will likely raise the prevalence of the condition have sparked questions over appropriate diagnostic tools and cost efficacy, researchers said here.

Cancer Risk Forces Actos Off French, German Markets

Drug regulators in Germany and France have ordered doctors to stop prescribing the type 2 diabetes drug pioglitazone (Actos), following a French study suggesting a heightened risk of bladder cancer.

Diet, Exercise Sufficient to Reduce Triglycerides

While cholesterol control is often balanced between statins and lifestyle changes, reducing triglycerides can usually be accomplished with diet and lifestyle changes alone, according to a new scientific statement from the American Heart Association.

Take Rosiglitazone Off the Market, Says FDA Staff

WASHINGTON -- Rosiglitazone (Avandia) should be pulled from the market because of the "serious" cardiovascular risk the diabetes drug poses, which exceeds that of competitor pioglitazone (Actos), FDA staff reviewers again recommended.

ACC: FDA Announces Review of ACCORD Data

ATLANTA -- The FDA said it will conduct a full review of findings from a study which concluded that neither aggressive lipid-lowering therapy nor tight blood pressure control reduced cardiovascular events in persons with diabetes.

Stinky Diabetes Drug May Result in Poor Adherence

An immediate-release form of the antidiabetic agent metformin has a dead fish odor that may cause patients to stop taking the drug, clinicians warned.

FDA Finds Oral Insulin Spray Safe for IND Use

The FDA approved Oral-lyn, an insulin spray treatment for type I and type II diabetes, for its Investigational New Drug program.

Kidney Disease Raises Risk of Hypoglycemia

WHEELING, W.Va. -- Dangerous hypoglycemic episodes are a significant risk for patients with chronic kidney disease, whether they have diabetes or not, researchers said.

Weight-Loss Trial Final Report: 52 Pounds of Fat Melted Away

WEST PALM BEACH, Fla. -- The official results are in: My ending weight was 231 pounds -- a loss of 52 pounds from my starting weight of 283 pounds in January 2008.

Pregnancy Risks Differ for Interracial Couples

STANFORD, Calif. -- The risk for some pregnancy complications may be greater when one partner is white and the other Asian, researchers found.

Normal Enzyme Levels May Hide Advanced Liver Fibrosis

MILAN, Italy -- Patients with nonalcoholic fatty liver disease but normal alanine aminotransferase (ALT) levels are still at risk of severe hepatic disease, researchers found.

Herpes Virus Linked to Ketosis-Prone Diabetes

PARIS -- A herpes virus is associated with an atypical form of type 2 diabetes found in people of African origin, researchers said here.

Boxed Heart Failure Warning Added to Two Diabetes Drugs

ROCKVILLE, Md. -- The makers of rosiglitazone (Avandia) and pioglitazone (Actos), have agreed to add a black box warning to the type 2 diabetes drugs' labels about an increased risk of heart failure, the FDA said today.

FDA Approves 'Gila Monster' Diabetes Drug

ROCKVILLE, Md.-The FDA announced today it has approved a new injectable diabetes drug synthesized from gila monster saliva, but says the drug should only be used in combination with older oral medications.